Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons

• Main Authors: Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Vashisht, Ajay, Wohlschlegel, James A., Martin, Kelsey C.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/79343; http://hdl.handle.net/10220/38742
• Institution: Nanyang Technological University

Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target gen...