Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons

• Main Authors: Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Vashisht, Ajay, Wohlschlegel, James A., Martin, Kelsey C.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2015
• 在線閱讀: https://hdl.handle.net/10356/79343; http://hdl.handle.net/10220/38742
• 機構: Nanyang Technological University

Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target gen...