A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

• Main Authors: Toh, Joel D. W., Sun, Lingyi, Lau, Lisa Z. M., Tan, Jackie, Low, Joanne J. A., Tang, Colin W. Q., Cheong, Eleanor J. Y., Tan, Melissa J. H., Chen, Yun, Hong, Wanjin, Gao, Yong-Gui, Woon, Esther C. Y.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/79355; http://hdl.handle.net/10220/25115
• Institution: Nanyang Technological University

The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular mechanisms are unclear, hence, there is strong interest in developing selective inhibitors for...