Structure of the human telomere in Na+ solution : an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity

• Main Authors: Lim, Kah Wai, Ng, Veronica Chinn Min, Martin-Pintado, Nerea, Heddi, Brahim, Phan, Anh Tuan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids
• Online Access: https://hdl.handle.net/10356/79374; http://hdl.handle.net/10220/18590
• Institution: Nanyang Technological University

Single-stranded DNA overhangs at the ends of human telomeric repeats are capable of adopting four-stranded G-quadruplex structures, which could serve as potential anticancer targets. Out of the five reported intramolecular human telomeric G-quadruplex structures, four were formed in the presence of...