Exposure to metals can be therapeutic
Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteri...
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| Format: | Article |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/79435 http://hdl.handle.net/10220/25592 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteristics of coordination geometry, redox state and ligand exchange allow one to fine-tune reactivity and affinity properties in a distinct fashion. This intersection of chromatin biology and bioinorganic medicinal chemistry is the subject of multiple collaborations in and between Switzerland and Singapore. |
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