Exposure to metals can be therapeutic

Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteri...

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Main Author:	Davey, Curtis Alexander
Other Authors:	School of Biological Sciences
Format:	Article
Language:	English
Published:	2015
Subjects:	DRNTU::Science::Chemistry
Online Access:	https://hdl.handle.net/10356/79435 http://hdl.handle.net/10220/25592
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-79435
record_format	dspace
spelling	sg-ntu-dr.10356-794352023-02-28T16:58:03Z Exposure to metals can be therapeutic Davey, Curtis Alexander School of Biological Sciences DRNTU::Science::Chemistry Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteristics of coordination geometry, redox state and ligand exchange allow one to fine-tune reactivity and affinity properties in a distinct fashion. This intersection of chromatin biology and bioinorganic medicinal chemistry is the subject of multiple collaborations in and between Switzerland and Singapore. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2015-05-18T08:52:01Z 2019-12-06T13:25:13Z 2015-05-18T08:52:01Z 2019-12-06T13:25:13Z 2015 2015 Journal Article Davey, C. A. (2015). Exposure to metals can be therapeutic. CHIMIA international journal for chemistry, 69(3), 125-130. 0009-4293 https://hdl.handle.net/10356/79435 http://hdl.handle.net/10220/25592 10.2533/chimia.2015.125 en CHIMIA international journal for chemistry © 2015 Schweizerische Chemische Gesellschaft. This paper was published in CHIMIA International Journal for Chemistry and is made available as an electronic reprint (preprint) with permission of Swiss Chemical Society. The paper can be found at the following official DOI: [http://dx.doi.org/10.2533/chimia.2015.125]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 6 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry
spellingShingle	DRNTU::Science::Chemistry Davey, Curtis Alexander Exposure to metals can be therapeutic
description	Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteristics of coordination geometry, redox state and ligand exchange allow one to fine-tune reactivity and affinity properties in a distinct fashion. This intersection of chromatin biology and bioinorganic medicinal chemistry is the subject of multiple collaborations in and between Switzerland and Singapore.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Davey, Curtis Alexander
format	Article
author	Davey, Curtis Alexander
author_sort	Davey, Curtis Alexander
title	Exposure to metals can be therapeutic
title_short	Exposure to metals can be therapeutic
title_full	Exposure to metals can be therapeutic
title_fullStr	Exposure to metals can be therapeutic
title_full_unstemmed	Exposure to metals can be therapeutic
title_sort	exposure to metals can be therapeutic
publishDate	2015
url	https://hdl.handle.net/10356/79435 http://hdl.handle.net/10220/25592
_version_	1759856836656234496

Exposure to metals can be therapeutic

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