Polymorphonuclear leukocytes restrict growth of pseudomonas aeruginosa in the lungs of cystic fibrosis patients

• Main Authors: Moser, Claus, Kragh, Kasper N., Alhede, Morten, Jensen, Peter Ø., Scheike, Thomas, Jacobsen, Carsten S., Poulsen, Steen Seier, Eickhardt-Sørensen, Steffen Robert, Trøstrup, Hannah, Christoffersen, Lars, Hougen, Hans-Petter, Rickelt, Lars F., Kühl, Michael, Høiby, Niels, Bjarnsholt, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/79443; http://hdl.handle.net/10220/25690
• Institution: Nanyang Technological University

Cystic fibrosis (CF) patients have increased susceptibility to chronic lung infections by Pseudomonas aeruginosa, but the ecophysiology within the CF lung during infections is poorly understood. The aim of this study was to elucidate the in vivo growth physiology of P. aeruginosa within lungs of chr...