Context-dependant role of mitochondrial fusion-fission in clonal expansion of mtDNA mutations

• Main Authors: Tam, Zhi Yang, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto
• Other Authors: Morozov, Alexandre V
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/79467; http://hdl.handle.net/10220/26112
• Institution: Nanyang Technological University

The accumulation of mutant mitochondrial DNA (mtDNA) molecules in aged cells has been associated with mitochondrial dysfunction, age-related diseases and the ageing process itself. This accumulation has been shown to often occur clonally, where mutant mtDNA grow in number and overpopulate the wild-t...