Context-dependant role of mitochondrial fusion-fission in clonal expansion of mtDNA mutations
The accumulation of mutant mitochondrial DNA (mtDNA) molecules in aged cells has been associated with mitochondrial dysfunction, age-related diseases and the ageing process itself. This accumulation has been shown to often occur clonally, where mutant mtDNA grow in number and overpopulate the wild-t...
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Main Authors: | Tam, Zhi Yang, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto |
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Other Authors: | Morozov, Alexandre V |
Format: | Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/79467 http://hdl.handle.net/10220/26112 |
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Institution: | Nanyang Technological University |
Language: | English |
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