Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints

• Main Authors: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Halliwell, Barry, Gruber, Jan, Gunawan, Rudiyanto
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Bioinformatics; Molecular Genetics
• Online Access: https://hdl.handle.net/10356/160676
• Institution: Nanyang Technological University

Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion mutations, details such as the specific DNA repair errors a...