Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints

Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion mutations, details such as the specific DNA repair errors a...

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Bibliographic Details
Main Authors: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Halliwell, Barry, Gruber, Jan, Gunawan, Rudiyanto
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/160676
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Institution: Nanyang Technological University
Language: English

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