Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity

• Main Authors: Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Kwoh, Chee Keong, Kuznetsov, Vladimir
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/79920; http://hdl.handle.net/10220/10922
• Institution: Nanyang Technological University

R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease...