Type I IFN signaling in CD8– DCs impairs Th1-dependent malaria immunity

• Main Authors: Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Montes de Oca, Marcela, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., de Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Haque, Ashraful, Best, Shannon E., Gun, Sin Yee, Rénia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R., Engwerda, Christian R.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2014
• 主題: DRNTU::Science::Medicine
• 在線閱讀: https://hdl.handle.net/10356/80006; http://hdl.handle.net/10220/20014
• 機構: Nanyang Technological University

Many pathogens, including viruses, bacteria, and protozoan parasites, suppress cellular immune responses through activation of type I IFN signaling. Recent evidence suggests that immune suppression and susceptibility to the malaria parasite, Plasmodium, is mediated by type I IFN; however, it is uncl...