Mannitol enhances antibiotic sensitivity of persister bacteria in Pseudomonas aeruginosa biofilms

• Main Authors: Rice, Scott A., Barraud, Nicolas, Buson, Alberto, Jarolimek, Wolfgang
• Other Authors: Beloin, Christophe
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/80009; http://hdl.handle.net/10220/18797
• Institution: Nanyang Technological University

The failure of antibiotic therapies to clear Pseudomonas aeruginosa lung infection, the key mortality factor for cystic fibrosis (CF) patients, is partly attributed to the high tolerance of P. aeruginosa biofilms. Mannitol has previously been found to restore aminoglycoside sensitivity in Escherichi...