Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

• Main Authors: Montagner, Alexandra, Korecka, Agata, Polizzi, Arnaud, Lippi, Yannick, Blum, Yuna, Canlet, Cécile, Tremblay-Franco, Marie, Gautier-Stein, Amandine, Burcelin, Rémy, Yen, Yi-Chun, Je, Hyunsoo Shawn, Maha, Al-Asmakh, Mithieux, Gilles, Arulampalam, Velmurugesan, Lagarrigue, Sandrine, Guillou, Hervé, Pettersson, Sven, Wahli, Walter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Medicine
• Online Access: https://hdl.handle.net/10356/80202; http://hdl.handle.net/10220/40393
• Institution: Nanyang Technological University

The liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well known. Here, we report that germ-...