Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles

Micro-optical coherence tomography tracking of magnetic gene transfection via Au–Fe3O4 dumbbell nanoparticles

Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coher...

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Bibliographic Details
Main Authors: Shi, Wei, Liu, Xinyu, Wei, Chao, Xu, Zhichuan J., Sim, Stanley Siong Wei, Liu, Linbo, Xu, Chenjie
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2016
Subjects:
Heterogeneous nanoparticles
Magnetofection
Gene delivery
Dumbbell nanoparticles
Micro-optical coherence tomography
Online Access:https://hdl.handle.net/10356/80244
http://hdl.handle.net/10220/40456
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Institution: Nanyang Technological University
Language: English
Description
Summary:Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.

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