Hedgehog signalling
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormaliti...
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2016
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sg-ntu-dr.10356-802572020-11-01T05:23:00Z Hedgehog signalling Lee, Raymond Teck Ho Zhao, Zhonghua Ingham, Philip William Lee Kong Chian School of Medicine (LKCMedicine) Drosophila Hedgehog signalling Vertebrate The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2016-04-15T02:46:02Z 2019-12-06T13:46:00Z 2016-04-15T02:46:02Z 2019-12-06T13:46:00Z 2016 Journal Article Lee, R. T. H., Zhao, Z., & Ingham, P. W. (2016). Hedgehog signalling. Development, 143(3), 367-372. https://hdl.handle.net/10356/80257 http://hdl.handle.net/10220/40416 10.1242/dev.120154 en Development © 2016 The Author(s). (published by The Company of Biologists Ltd.). This paper was published in Development and is made available as an electronic reprint (preprint) with permission of The Company of Biologists Ltd. The published version is available at: [http://dx.doi.org/10.1242/dev.120154]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 6 p. application/pdf |
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Nanyang Technological University |
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NTU Library |
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Asia |
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Singapore Singapore |
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English |
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Drosophila Hedgehog signalling Vertebrate |
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Drosophila Hedgehog signalling Vertebrate Lee, Raymond Teck Ho Zhao, Zhonghua Ingham, Philip William Hedgehog signalling |
| description |
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Lee, Raymond Teck Ho Zhao, Zhonghua Ingham, Philip William |
| format |
Article |
| author |
Lee, Raymond Teck Ho Zhao, Zhonghua Ingham, Philip William |
| author_sort |
Lee, Raymond Teck Ho |
| title |
Hedgehog signalling |
| title_short |
Hedgehog signalling |
| title_full |
Hedgehog signalling |
| title_fullStr |
Hedgehog signalling |
| title_full_unstemmed |
Hedgehog signalling |
| title_sort |
hedgehog signalling |
| publishDate |
2016 |
| url |
https://hdl.handle.net/10356/80257 http://hdl.handle.net/10220/40416 |
| _version_ |
1683493957560958976 |