An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

The G-protein-coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock-down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...

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Bibliographic Details
Main Authors: Zhao, Zhonghua, Lee, Raymond Teck Ho, Pusapati, Ganesh V., Iyu, Audrey, Rohatgi, Rajat, Ingham, Philip William
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
Subjects:
Grk2
Hedgehog signalling
phosphorylation
PKA
Smo
Online Access:https://hdl.handle.net/10356/80521
http://hdl.handle.net/10220/40517
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/80521
http://hdl.handle.net/10220/40517

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