An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
The G-protein-coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock-down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...
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Main Authors: | Zhao, Zhonghua, Lee, Raymond Teck Ho, Pusapati, Ganesh V., Iyu, Audrey, Rohatgi, Rajat, Ingham, Philip William |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/80521 http://hdl.handle.net/10220/40517 |
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Institution: | Nanyang Technological University |
Language: | English |
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