An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

• Main Authors: Zhao, Zhonghua, Lee, Raymond Teck Ho, Pusapati, Ganesh V., Iyu, Audrey, Rohatgi, Rajat, Ingham, Philip William
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Grk2; Hedgehog signalling; phosphorylation; PKA; Smo
• Online Access: https://hdl.handle.net/10356/80521; http://hdl.handle.net/10220/40517
• Institution: Nanyang Technological University

The G-protein-coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock-down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...