Using Diphenylphosphoryl Azide (DPPA) for the facile synthesis of biodegradable antiseptic random copolypeptides

• المؤلفون الرئيسيون: Pu, Yuji, Du, Yu, Khin, Mya Mya, Ravikumar, Vikashini, Rice, Scott A., Duan, Hongwei, Chan-Park, Mary B.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Antibacterial Peptides; Broad-spectrum Antibacterial Activity
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/80350; http://hdl.handle.net/10220/45009

We have developed a facile method for the large-scale synthesis of random copolypeptides composed of multiple (i.e. cationic, hydrophobic, and hydrophilic) amino acids and have optimized their relative ratios for broad-spectrum antibacterial effect. The copolypeptides obtained have measured composit...