Nanoparticles of short cationic peptidopolysaccharide self-assembled by hydrogen bonding with antibacterial effect against multidrug-resistant bacteria

• Main Authors: Hou, Zheng, Shankar, Yogesh Vikhe, Liu, Yang, Ding, Feiqing, Subramanion, Jothy Lachumy, Ravikumar, Vikashini, Zamudio-Vázquez, Rubí, Keogh, Damien, Lim, Huiwen, Tay, Moon Yue Feng, Bhattacharjya, Surajit, Rice, Scott A., Shi, Jian, Duan, Hongwei, Liu, Xue-Wei, Mu, Yuguang, Tan, Nguan Soon, Tam, Kam C., Pethe, Kevin, Chan-Park, Mary B.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Antibacterial; Short Peptidopolysaccharide
• Online Access: https://hdl.handle.net/10356/80357; http://hdl.handle.net/10220/45010
• Institution: Nanyang Technological University

Cationic antimicrobial peptides (AMPs) and polymers are active against many multi-drug resistant (MDR) bacteria but only a limited number of these compounds are in clinical use due to their unselective toxicity. The typical strategy for achieving selective antibacterial efficacy with low mammalian c...