The effect of polyethylene glycol structure on paclitaxel drug release and mechanical properties of PLGA thin films

• Main Authors: Steele, Terry W. J., Huang, Charlotte L., Widjaja, Effendi, Boey, Freddy Y. C., Loo, Joachim Say Chye, Venkatraman, Subbu S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Raman spectra; Poly-lactide-co-glycolide
• Online Access: https://hdl.handle.net/10356/80497; http://hdl.handle.net/10220/42161
• Institution: Nanyang Technological University

Thin films of poly(lactic acid-co-glycolic acid) (PLGA) incorporating paclitaxel typically have slow release rates of paclitaxel of the order of 1 μg day−1 cm−2. For implementation as medical devices a range of zero order release rates (i.e. 1–15 μg day−1 cm−2) is desirable for different tissues and...