Transformation of Cortex-wide Emergent Properties during Motor Learning
Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks....
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sg-ntu-dr.10356-805282020-03-07T12:57:21Z Transformation of Cortex-wide Emergent Properties during Motor Learning Makino, Hiroshi Ren, Chi Liu, Haixin Kim, An Na Kondapaneni, Neehar Liu, Xin Kuzum, Duygu Komiyama, Takaki Lee Kong Chian School of Medicine (LKCMedicine) Motor learning Wide-field calcium imaging Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements. 2017-07-25T02:00:40Z 2019-12-06T13:51:31Z 2017-07-25T02:00:40Z 2019-12-06T13:51:31Z 2017 Journal Article Makino, H., Ren, C., Liu, H., Kim, A. N., Kondapaneni, N., Liu, X., et al. (2017). Transformation of Cortex-wide Emergent Properties during Motor Learning. Neuron, 94(4), 880-890.e8. 0896-6273 https://hdl.handle.net/10356/80528 http://hdl.handle.net/10220/43426 10.1016/j.neuron.2017.04.015 en Neuron © 2017 Elsevier Inc. |
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Motor learning Wide-field calcium imaging Makino, Hiroshi Ren, Chi Liu, Haixin Kim, An Na Kondapaneni, Neehar Liu, Xin Kuzum, Duygu Komiyama, Takaki Transformation of Cortex-wide Emergent Properties during Motor Learning |
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Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Makino, Hiroshi Ren, Chi Liu, Haixin Kim, An Na Kondapaneni, Neehar Liu, Xin Kuzum, Duygu Komiyama, Takaki |
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Article |
author |
Makino, Hiroshi Ren, Chi Liu, Haixin Kim, An Na Kondapaneni, Neehar Liu, Xin Kuzum, Duygu Komiyama, Takaki |
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Makino, Hiroshi |
title |
Transformation of Cortex-wide Emergent Properties during Motor Learning |
title_short |
Transformation of Cortex-wide Emergent Properties during Motor Learning |
title_full |
Transformation of Cortex-wide Emergent Properties during Motor Learning |
title_fullStr |
Transformation of Cortex-wide Emergent Properties during Motor Learning |
title_full_unstemmed |
Transformation of Cortex-wide Emergent Properties during Motor Learning |
title_sort |
transformation of cortex-wide emergent properties during motor learning |
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2017 |
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https://hdl.handle.net/10356/80528 http://hdl.handle.net/10220/43426 |
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1681045339615789056 |