Transformation of Cortex-wide Emergent Properties during Motor Learning

Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks....

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Main Authors: Makino, Hiroshi, Ren, Chi, Liu, Haixin, Kim, An Na, Kondapaneni, Neehar, Liu, Xin, Kuzum, Duygu, Komiyama, Takaki
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2017
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Online Access:https://hdl.handle.net/10356/80528
http://hdl.handle.net/10220/43426
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-805282020-03-07T12:57:21Z Transformation of Cortex-wide Emergent Properties during Motor Learning Makino, Hiroshi Ren, Chi Liu, Haixin Kim, An Na Kondapaneni, Neehar Liu, Xin Kuzum, Duygu Komiyama, Takaki Lee Kong Chian School of Medicine (LKCMedicine) Motor learning Wide-field calcium imaging Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements. 2017-07-25T02:00:40Z 2019-12-06T13:51:31Z 2017-07-25T02:00:40Z 2019-12-06T13:51:31Z 2017 Journal Article Makino, H., Ren, C., Liu, H., Kim, A. N., Kondapaneni, N., Liu, X., et al. (2017). Transformation of Cortex-wide Emergent Properties during Motor Learning. Neuron, 94(4), 880-890.e8. 0896-6273 https://hdl.handle.net/10356/80528 http://hdl.handle.net/10220/43426 10.1016/j.neuron.2017.04.015 en Neuron © 2017 Elsevier Inc.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Motor learning
Wide-field calcium imaging
spellingShingle Motor learning
Wide-field calcium imaging
Makino, Hiroshi
Ren, Chi
Liu, Haixin
Kim, An Na
Kondapaneni, Neehar
Liu, Xin
Kuzum, Duygu
Komiyama, Takaki
Transformation of Cortex-wide Emergent Properties during Motor Learning
description Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Makino, Hiroshi
Ren, Chi
Liu, Haixin
Kim, An Na
Kondapaneni, Neehar
Liu, Xin
Kuzum, Duygu
Komiyama, Takaki
format Article
author Makino, Hiroshi
Ren, Chi
Liu, Haixin
Kim, An Na
Kondapaneni, Neehar
Liu, Xin
Kuzum, Duygu
Komiyama, Takaki
author_sort Makino, Hiroshi
title Transformation of Cortex-wide Emergent Properties during Motor Learning
title_short Transformation of Cortex-wide Emergent Properties during Motor Learning
title_full Transformation of Cortex-wide Emergent Properties during Motor Learning
title_fullStr Transformation of Cortex-wide Emergent Properties during Motor Learning
title_full_unstemmed Transformation of Cortex-wide Emergent Properties during Motor Learning
title_sort transformation of cortex-wide emergent properties during motor learning
publishDate 2017
url https://hdl.handle.net/10356/80528
http://hdl.handle.net/10220/43426
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