Quantification of aldehyde terminated heparin by SEC-MALLS-UV for the surface functionalization of polycaprolactone biomaterials

• Main Authors: Irvine, Scott Alexander, Steele, Terry W. J., Bhuthalingam, Ramya, Li, Min, Boujday, Souhir, Prawirasatya, Melissa, Neoh, Koon Gee, Boey, Freddy Yin Chiang, Venkatraman, Subbu S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Heparin; Aniline
• Online Access: https://hdl.handle.net/10356/80595; http://hdl.handle.net/10220/42175
• Institution: Nanyang Technological University

A straight forward strategy of heparin surface grafting employs a terminal reactive-aldehyde group introduced through nitrous acid depolymerization. An advanced method that allows simultaneously monitoring of both heparin molar mass and monomer/aldehyde ratio by size exclusion chromatography, multi-...