Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

• Main Authors: Smith, Raymond A. A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J. L., Nurcombe, Victor, Cool, Simon M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Heparin; Glycosaminoglycan
• Online Access: https://hdl.handle.net/10356/143973
• Institution: Nanyang Technological University

Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan classes were compared and shown to be selective for...