Cell-selective pore forming antimicrobial peptides of the prodomain of human furin : a conserved aromatic/cationic sequence mapping, membrane disruption, and atomic-resolution structure and dynamics

• Main Authors: Sinha, Sheetal, Harioudh, Munesh Kumar, Dewangan, Rikeshwer P., Ng, Wun Jern, Ghosh, Jimut Kanti, Bhattacharjya, Surajit
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Pore Forming; Human Furin; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/80710; http://hdl.handle.net/10220/50373
• Institution: Nanyang Technological University

Antimicrobial peptides are promising molecules in uprising consequences of drug-resistant bacteria. The prodomain of furin, a serine protease, expressed in all vertebrates including humans, is known to be important for physiological functions. Here, potent antimicrobial peptides were mapped by exten...