Effect of iron overload on furin expression in wild-type and β-thalassemic mice

• Main Authors: Surasak Wichaiyo, Paranee Yatmark, Ronald Enrique Morales Vargas, Pimtip Sanvarinda, Saovaros Svasti, Suthat Fucharoen, Noppawan Phumala Morales
• Other Authors: Mahidol University. Institute of Molecular Biosciences. Thalassemia Research Center
• Format: Article
• Language: English
• Published: 2016
• Subjects: Furin; Hepcidin; Iron overload; β-Thalassemic mice; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/1839
• Institution: Mahidol University

Furin is a proprotein convertase enzyme. In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis. Hepcidin deficiency is a component of several iron overload disorders, including β-thalassemia. Several studies have identified factors that repress he...