Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells

• Main Authors: Mattout, Anna, Aaronson, Yair, Sailaja, Badi Sri, Raghu Ram, Edupuganti V., Harikumar, Arigela, Mallm, Jan-Philipp, Sim, Kae Hwan, Nissim-Rafinia, Malka, Supper, Emmanuelle, Singh, Prim B., Sze, Siu Kwan, Gasser, Susan M., Rippe, Karsten, Meshorer, Eran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/81001; http://hdl.handle.net/10220/39029
• Institution: Nanyang Technological University

Background: Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural...