Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

• Main Authors: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther S. M., Lim, John S. Y., Mutalif, Rafidah A., Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y., Sze, Siu Kwan, Boudier, Thomas, Wright, Graham D., Colman, Alan, Burke, Brian, Stewart, Colin L., Dreesen, Oliver
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/81002; http://hdl.handle.net/10220/39046
• Institution: Nanyang Technological University

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...