Rupture of Lipid Vesicles by a Broad-Spectrum Antiviral Peptide: Influence of Vesicle Size

• Main Authors: Zan, Goh Haw, Zhdanov, Vladimir P., Cho, Nam-Joon, Jackman, Joshua Alexander
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Materials Science and Engineering; Chemical and Biomedical Engineering
• Online Access: https://hdl.handle.net/10356/81034; http://hdl.handle.net/10220/40641
• Institution: Nanyang Technological University

An amphipathic α-helical (AH) peptide was recently discovered that can rupture the lipid envelope of many viruses including HIV, hepatitis C, dengue, and herpes simplex. Despite its broad-spectrum activity, the AH peptide specifically targets small viruses only and does not affect large viruses. Ind...