Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex

• Main Authors: Nadeem, Aftab, Sanborn, Jeremy, Gettel, Douglas L., Ho, James C. S., Pedersen, Stine Falsig, Lam, Matti, Rydström, Anna, Ngassam, Viviane N., Klausen, Thomas Kjær, Parikh, Atul N., Svanbor, Catharina
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/81086; http://hdl.handle.net/10220/39063
• Institution: Nanyang Technological University

A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This ‘’protein-centric” view is increasingly challenged by evidence for the involvement of specialized membrane domains in signa...