Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactive nuclear compartments

• Main Authors: Markaki, Yolanda, Ferrari, Sergio, Cremer, Marion, Hübner, Barbara, Lomiento, Mariana, Mammoli, Fabiana, Illner, Doris, Cremer, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Myelopoiesis; Somatic cell differentiation; Nuclear architecture; Active nuclear compartment; Interchromatin compartment; Perichromatin region; Super-resolution microscopy; Electron microscopy; Chromatin domain; Chromatin density classification
• Online Access: https://hdl.handle.net/10356/81119; http://hdl.handle.net/10220/39099
• Institution: Nanyang Technological University

Background: Previous studies of higher order chromatin organization in nuclei of mammalian species revealed both structural consistency and species-specific differences between cell lines and during early embryonic development. Here, we extended our studies to nuclear landscapes in the human myelop...