RNA sensing by conventional dendritic cells is central to the development of lupus nephritis

• Main Authors: Celhar, Teja, Hopkins, Richard, Thornhill, Susannah I., De Magalhaes, Raquel, Hwang, Sun-Hee, Lee, Hui-Yin, Yasuga, Hiroko, Jones, Leigh A., Casco, Jose, Lee, Bernett, Thamboo, Thomas P., Zhou, Xin J., Poidinger, Michael, Connolly, John E., Wakeland, Edward K., Fairhurst, Anna-Marie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Dendritic cells; SLE; Autoimmunity; TLR7; Nephritis
• Online Access: https://hdl.handle.net/10356/81194; http://hdl.handle.net/10220/39173
• Institution: Nanyang Technological University

Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SLE). The precise immune mechanisms that drive the progression from benign autoimmunity to glomerulonephritis are largely unknown. Previous investigations have shown that a moderate increase of the innate Toll-l...