iTRAQ Quantitative Clinical Proteomics Revealed Role of Na+K+ -ATPase and Its Correlation with Deamidation in Vascular Dementia

• Main Authors: Adav, Sunil S., Qian, Jingru, Ang, Yi Lin, Kalaria, Raj N., Lai, Mitchell K. P., Chen, Christopher P., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: dementia; Na+/K+-ATPase; ion channel proteins; iTRAQ; mass spectrometry
• Online Access: https://hdl.handle.net/10356/81220; http://hdl.handle.net/10220/39155
• Institution: Nanyang Technological University

Dementia is a major public health burden characterized by impaired cognition and loss of function. There are limited treatment options due to inadequate understanding of its pathophysiology and underlying causative mechanisms. Discovery-driven iTRAQ-based quantitative proteomics techniques were appl...