Metabolic reprogramming of tumor-infiltrating myeloid cells conveys protection against pancreatic ductal adenocarcinoma

• Main Author: Sieow, Je Lin
• Other Authors: Wong Siew Cheng
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/81283; http://hdl.handle.net/10220/47516
• Institution: Nanyang Technological University

Myriad mechanisms of immune evasion contribute to therapeutic resistance of pancreatic cancer and poor survival. While it is well established that tumor cells exhibit the Warburg effect for energy production, the contribution of myeloid cell metabolism to disease progression is unknown. In this stud...