Type Six Secretion System of Bordetella bronchiseptica and Adaptive Immune Components Limit Intracellular Survival During Infection

• Main Authors: Bendor, Liron, Weyrich, Laura S., Linz, Bodo, Rolin, Olivier Y., Taylor, Dawn L., Goodfield, Laura L., Smallridge, William E., Kennett, Mary J., Harvill, Eric Thomas
• Other Authors: Jeyaseelan, Samithamby
• Format: Article
• Language: English
• Published: 2015
• Subjects: Medicine
• Online Access: https://hdl.handle.net/10356/81318; http://hdl.handle.net/10220/39220
• Institution: Nanyang Technological University

The Type Six Secretion System (T6SS) is required for Bordetella bronchiseptica cytotoxicity, cytokine modulation, infection, and persistence. However, one-third of recently sequenced Bordetella bronchiseptica strains of the predominantly human-associated Complex IV have lost their T6SS through gene...