Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon

• Main Authors: Abdul Rashid Mohammad Muzaki, Soncin, Irene, Setiagani, Yolanda Aphrilia, Sheng, Jianpeng, Tetlak, Piotr, Karjalainen, Klaus, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: T Cells; Colon; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/81392; http://hdl.handle.net/10220/49069
• Institution: Nanyang Technological University

Intestinal IL-17–producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17–producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minim...