Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

• Main Authors: Fukawa, Tomoya, Ong, Pauline, Li, Zhimei, Chen, Shuwen, Mak, Shi Ya, Kanayama, Hiro-omi, Mohan, Rosmin Elsa, Wang, Ruiqi Rachel, Chua, Benjamin Yan-Jiang, Chua, Jason Min-Wen, Tan, Elwin Jun-Hao, Huang, Dan, Qian, Chao-Nan, Lim, Wan Jun, Lai, Jiunn Herng, Chua, Clarinda, Ong, Hock Soo, Tan, Ker-Kan, Ho, Ying Swan, Tan, Iain Beehuat, Teh, Bin Tean, Ng, Shyh-Chang
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Metabolic disorders; Cancer models
• Online Access: https://hdl.handle.net/10356/81480; http://hdl.handle.net/10220/42251
• Institution: Nanyang Technological University

Cachexia is a devastating muscle-wasting syndrome that occurs in patients who have chronic diseases. It is most commonly observed in individuals with advanced cancer1, 2, presenting in 80% of these patients, and it is one of the primary causes of morbidity and mortality associated with cancer3, 4, 5...