Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells

• المؤلفون الرئيسيون: Carlevaro-Fita, Joana, Rahim, Anisa, Guigó, Roderic, Johnson, Rory, Vardy, Leah Karen Anne
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Cytoplasm; Transposable element; Ribosome profiling; Degradation; Long noncoding RNA; Ribosome; Translation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81504; http://hdl.handle.net/10220/40809
• المؤسسة: Nanyang Technological University

Recent footprinting studies have made the surprising observation that long noncoding RNAs (lncRNAs) physically interact with ribosomes. However, these findings remain controversial, and the overall proportion of cytoplasmic lncRNAs involved is unknown. Here we make a global, absolute estimate of the...