Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells

• Main Authors: Carlevaro-Fita, Joana, Rahim, Anisa, Guigó, Roderic, Johnson, Rory, Vardy, Leah Karen Anne
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2016
• 主題: Cytoplasm; Transposable element; Ribosome profiling; Degradation; Long noncoding RNA; Ribosome; Translation
• 在線閱讀: https://hdl.handle.net/10356/81504; http://hdl.handle.net/10220/40809

Recent footprinting studies have made the surprising observation that long noncoding RNAs (lncRNAs) physically interact with ribosomes. However, these findings remain controversial, and the overall proportion of cytoplasmic lncRNAs involved is unknown. Here we make a global, absolute estimate of the...