Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

• Main Authors: Meredith, Erik L., Mainolfi, Nello, Poor, Stephen, Qiu, Yubin, Miranda, Karl, Powers, James, Liu, Donglei, Ma, Fupeng, Solovay, Catherine, Rao, Chang, Johnson, Leland, Ji, Nan, Artman, Gerald, Hardegger, Leo, Hanks, Shawn, Shen, Siyuan, Woolfenden, Amber, Fassbender, Elizabeth, Sivak, Jeremy M., Zhang, Yiqin, Long, Debby, Cepeda, Rosemarie, Liu, Fang, Hosagrahara, Vinayak P., Lee, Wendy, Tarsa, Peter, Anderson, Karen, Elliott, Jason, Jaffee, Bruce
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: pyrimidine derivative; capsule endoscope
• Online Access: https://hdl.handle.net/10356/81558; http://hdl.handle.net/10220/39573
• Institution: Nanyang Technological University

The benefit of intravitreal anti-VEGF therapy in treating wet age-related macular degeneration (AMD) is well established. Identification of VEGFR-2 inhibitors with optimal ADME properties for an ocular indication provides opportunities for dosing routes beyond intravitreal injection. We employed a h...