Microfluidic platform for negative enrichment of circulating tumor cells

• Main Authors: Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Khuntontong, Puttachat, Wong, Chee Chung, Wang, Zhiping, Puiu, Poenar Daniel, Soo, Ross, Rahman, Abdur Rub Abdur
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Circulating tumor cells (CTCs); Cancer cell isolation
• Online Access: https://hdl.handle.net/10356/81639; http://hdl.handle.net/10220/40875
• Institution: Nanyang Technological University

Negative enrichment is the preferred approach for tumor cell isolation as it does not rely on biomarker expression. However, size-based negative enrichment methods suffer from well-known recovery/purity trade-off. Non-size based methods have a number of processing steps that lead to compounded cell...