The Basophil Surface Marker CD203c Identifies Aspergillus Sensitization in 2 Cystic Fibrosis

• Main Authors: Mirković, Bojana, Lavelle, Gillian M., Azim, Ahmed Abdul, Helma, Kristine, Gargoum, Fatma S., Molloy, Kevin, Gernez, Yael, Dunne, Katie, Renwick, Julie, Murphy, Philip, Moss, Richard B., Greene, Catherine M., Gunaratnam, Cedric, Chotirmall, Sanjay Haresh, McElvaney, Noel G.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Basophil activation test; CD203c; Cystic fibrosis; Aspergillus fumigatus; Body mass index; Flow cytometry; FEV1; Itraconazole, sensitization; Allergic bronchopulmonary aspergillosis
• Online Access: https://hdl.handle.net/10356/81769; http://hdl.handle.net/10220/39941
• Institution: Nanyang Technological University

Background: Colonization by Aspergillus fumigatus in patients with cystic fibrosis (CF) can cause A fumigatus sensitization and/or allergic bronchopulmonary aspergillosis (ABPA), which affects pulmonary function and clinical outcomes. Recent studies show that specific allergens upregulate the surfac...