Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis

• Main Authors: Gernez, Yael, Waters, Jeffrey, Mirković, Bojana, Lavelle, Gillian M., Dunn, Colleen E., Davies, Zoe A., Everson, Cassie, Tirouvanziam, Rabindra, Silver, Elana, Wallenstein, Sylvan, Chotirmall, Sanjay Haresh, McElvaney, Noel G., Herzenberg, Leonore A., Moss, Richard B.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Blood basophil surface; CD203c level
• Online Access: https://hdl.handle.net/10356/83009; http://hdl.handle.net/10220/42388
• Institution: Nanyang Technological University

The diagnosis of cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA) is clinically challenging, due to the absence of an objective biological test. Since blood basophils play a major role in allergic responses, we hypothesised that changes in their surface activation pa...