Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis

• Main Authors: Gernez, Yael, Waters, Jeffrey, Mirković, Bojana, Lavelle, Gillian M., Dunn, Colleen E., Davies, Zoe A., Everson, Cassie, Tirouvanziam, Rabindra, Silver, Elana, Wallenstein, Sylvan, Chotirmall, Sanjay Haresh, McElvaney, Noel G., Herzenberg, Leonore A., Moss, Richard B.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2017
• 主題: Blood basophil surface; CD203c level
• 在線閱讀: https://hdl.handle.net/10356/83009; http://hdl.handle.net/10220/42388

The diagnosis of cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA) is clinically challenging, due to the absence of an objective biological test. Since blood basophils play a major role in allergic responses, we hypothesised that changes in their surface activation pa...