mAb806 binding to epidermal growth factor receptor: a computational study

• المؤلفون الرئيسيون: Ng, Yao Zong, Kannan, Srinivasaraghavan, Lane, David P., Fuentes, Gloria, Verma, Chandra Shekhar
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: EGFR; extracellular domain
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81819; http://hdl.handle.net/10220/40979

The epidermal growth factor receptor (EGFR) is an important target in the treatment of cancer. A very potent antibody, mAb806, has been developed against overexpressed EGFR and was found to be particularly active in brain tumors. Structural studies reveal that it binds to an epitope on the extracell...