Generalized logical model based on network topology to capture the dynamical trends of cellular signaling pathways

• Main Authors: Zhang, Fan, Chen, Haoting, Zhao, Li Na, Liu, Hui, Przytycka, Teresa M., Zheng, Jie
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Generalized logical model; Signaling pathways; Dynamical system; Cancer
• Online Access: https://hdl.handle.net/10356/81868; http://hdl.handle.net/10220/39714
• Institution: Nanyang Technological University

Background: Cellular responses to extracellular perturbations require signaling pathways to capture and transmit the signals. However, the underlying molecular mechanisms of signal transduction are not yet fully understood, thus detailed and comprehensive models may not be available for all the sign...