Bio-inspired micropatterned hydrogel to direct and deconstruct hierarchical processing of geometry-force signals by human mesenchymal stem cells during smooth muscle cell differentiation

• Main Authors: Tay, Chor Yong, Wu, Yun-Long, Cai, Pingqiang, Tan, Nguan Soon, Chen, Xiaodong, Tan, Lay Poh, Venkatraman, Subbu S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biomimetics; Stem cells
• Online Access: https://hdl.handle.net/10356/81892; http://hdl.handle.net/10220/39731
• Institution: Nanyang Technological University

Micropatterned biomaterial-based hydrogel platforms allow the recapitulation of in vivo-like microstructural and biochemical features that are critical physiological regulators of stem cell development. Herein, we report the use of muscle mimicking geometries patterned on polyacrylamide hydrogels as...