Human mesenchymal stem-cell behaviour on direct laser micropatterned electrospun scaffolds with hierarchical structures

• Main Authors: Li, Huaqiong, Wong, Yee Shan, Wen, Feng, Ng, Kee Woei, Ng, Gary Ka Lai, Venkatraman, Subbu S., Boey, Freddy Yin Chiang, Tan, Lay Poh
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/101674; http://hdl.handle.net/10220/19695
• Institution: Nanyang Technological University

Direct laser machining and electrospinning are utilized to obtain a bi-layered hybrid scaffold with hierarchical topographical features to mimic extracellular matrix-like microenvironment of cells. Adult bone marrow derived human mesenchymal stem cells (hMSCs) are cultured in vitro in these hybrid s...